The Science - ActiveItem
STEM CELLS:
ANCIENT SECRETS, 21st CENTURY SCIENCE
ACTIVEITEM™: THE DAWN OF A NEW ERA
Adult pluripotent stem cells are only found in placenta and have a unique role for the human body. They are pure potential, with no tissue-specific characteristics. They can become the stem cells of any tissue in the body.
Throughout history, going back thousands of years, a minority of healers have stumbled on the power of stem cells, without knowing what they were. They have used extracts from the placenta, or the umbilical cord, to create remarkable results. Some have even discovered that these benefits are tissue- specific, not species-specific.
Those unique characteristics were illustrated by the well- documented work of Dr. Jean-Baptiste Denys in 1667, when he transfused the blood of a lamb to a young dying man, who then survived and prospered. The success of the first recorded blood transfusion from animal to human started the trend of these procedures in Europe, and later, the Americas.
THE NEW SCIENCE OF STEM CELL
In the modern era, it was the Soviets, and particularly their sports scientists, who grasped the true potential of this natural resource. The astonishing successes they achieved were almost entirely based on the use of stem cells.
More recently, Western science has made rapid progress with stem cell medicine. Today, that progress is accelerating almost monthly as one breakthrough after
another is published in the journals and then broadcast to the press.
All of us are waking up to the fact that medicine could be totally transformed in a generation by the application of these new discoveries. Instead of organ transplants, we can expect patients to grow new organs. In place of prosthetics, they could even be growing new limbs. Adult stem cells from placenta are nature’s way of giving us the ability to start afresh, using young, undifferentiated cells to create whatever is needed.
AN INCREDIBLE SOLUTION THAT IS CHANGING THE STEM CELL PLAYING FIELD
Therapeutic use of stem cell transplants of animal origin in 70+ million patients over the last 80 years has accumulated sufficient data to prove that stem cell xeno-transplantation is not dangerous to an individual patient or to a mankind.
Stem cells of animal origin are equally effective, and safer, for stem cell transplantation treatment. They also eliminate all troubles associated with human stem cells (i.e. moral, ethical, religious, etc.).
‘Res ipsa loquitur’ (‘matters speak for themselves’): there is no real difference between xenotransplantation - (transplanting organs or tissues between members of different species) and allotransplantation – (transplanting organs or tissues between members of the same species) in clinical effectiveness. Meaning when applicable tissue can be used from either the same species or a different species, the clinical effectiveness of either is equal. This was recognized by
Dr P. Niehans, a Swiss doctor who was one of the developers of cellular therapy in the 1930’s and by all scientific leaders of German cell therapy in the 1950’s. For that reason, there was no was no concern about inability to use stem cells due to the prevailing ethical, moral, and religious, attitudes in western European countries.
When you place human and animal stem cells side-by-side, you find out that they look alike. Even most of the available cell-surface markers are the same. The only way to tell the cells of one species from another is by their karyotype, the number and shape of chromosomes, (temporary structures created from the genetic material of each cell during one short phase of cell division).
There is only one primary, biological difference between Homo sapiens and the rest of mammals: the frontal lobe of the brain. The rest of the body of all members of animal kingdom, including man, is the same on cytological (cellular) level.
Human cell transplantation (allotransplantation), is not, and will not, be better than, or superior to, (xenotransplantation) as the therapeutic tool in human medicine until the quality of stem cell allotransplants matches that of stem cell xenotransplants.
That would happen only if human beings would be kept in closed colonies, and the unthinkable practice of euthanasia would be permitted in the preparation of human stem cell transplants.
The main point is this. Animals would make a much better quality and source of cells for transplants. Animal material can always be obtained “fresh”, meaning the cells are 100% viable and active when collected. The same could hardly ever be stated about human collected material, where for obvious reasons there is always a delay between the time of birth and the actual collection of the material, so that the viability (activity) of cells at the time of their implantation into the patient’s body or planting onto the tissue culture medium, is often in doubt.
Preparation of stem cell xeno-transplants begins immediately after the natural healthy vaginal birth of the baby animal, while collection of remaining amniotic fluid (allo-transplants) must await long after the cesarean section surgery is finished, and the mother and the baby safely moved to their hospital room, and it is non-viable/inactive/dormant for many hours by then.
Can Animal Cells Transform the Worn Out Cells of Humans?
The idea of healing with animal or human organs is as old as medical history itself. As early as 360 B.C., the Greek philosopher and scientist Aristotle mentions a number of preparations consisting of animal or human organs. Paracelsus, the best-known physician of the 16th century, postulated "heart heals heart, kidney heals kidney". Towards the end of the last and the beginning of this century, surgeons transplanted whole glands such as testes and ovaries. The Russian surgeon Professor Voronoff acquired certain fame by transplanting monkey testes in elderly men.
The modern treatment methods of cellular therapy were developed by the Swiss surgeon mentioned earlier in this paper, (Dr. Paul Niehans). Initially, he also transplanted complete glands. He later went on to implant thin strips of glandular tissue into a muscle pocket. He logically replaced the existing method of surgically transplanting organs and partial organs with the implantation of cell and organ suspensions, which he called cellular therapy. The advantage of this method is the implanted cells are put in direct contact with the body fluids of the host.
In this way, the host body can absorb and process the implant material faster. The first cell implantation by Niehans in 1931 was a convincing success. After a failed thyroid operation, Professor De Quervain referred a woman with severe cramps to Niehans.
He saved her life by implanting an animal adrenal suspension. The importance of Niehans' contribution lies not so much in the introduction of this technical modification but in the fact that he systematically implanted not only the usual glands, but all organs and tissues of the body, e.g., animal heart, liver and brain.
Niehans intuitively anticipated findings and put them into practice although they were only scientifically confirmed many years later by Nobel Prize laureates (1960) Medawar and Burnet.
Well established scientific data has explained why stem cell xeno-transplants can be used instead of stem cell allo-transplants with a ’state-of-art’ safety. This has been known since the late 9th century, and our entire modern cell biology is based on the fact that all eukaryotic cells in nature are built and function according to the same laws. In clinical practice of stem cell transplantation, we have been dealing with eukaryotic cells (of mammals) only.
Main cells of the same organ or tissue are the same in Nature, (or nearly the same), regardless of the species of origin, i.e. corresponding cells of the identical organ of different animal species (including man) are biologically similar.
We could make a similar statement about any of approximately 200 – 225 types of cells of human or animal body. This scientific ‘principle of organospecificity’, described in German and Soviet/Russian literature decades ago, is still an unknown term in US medical journals. There are no antigenic differences between the corresponding cells of the identical organ of different animal species, including man. This is another proof of ‘organospecificity’. All biological systems in Nature are composed of the same types of molecules. The great majority of proteins from different organisms, including man, is similar over the entire amino acid sequence, i.e. they are homologous, (the same) of each other and in general carry out similar functions.
Homologous proteins evolved over billions of years from a common ancestor, and logically established a ‘principle of homology’. The basic law of molecular biology, whereby DNA directs the synthesis of RNA, that in turn controls the assembly of proteins, applies to all living beings.
Genetic encoding is the same in most known organisms. Families of similar genes encode proteins with similar functions. In (stem) cell transplantation it makes minimal difference whether one is dealing with xeno-transplantation or allo-transplantation when it comes to science.
But there is an enormous difference in medical practice, since with stem cell xeno-transplantation we can already treat hundreds of thousands of patients suffering from those diseases that cannot be cured or treated by any other therapy.
Stem cell xeno-transplants, especially ingestible, can be prepared for nearly limitless number of people, and ultimately at low cost. Therapeutic use of stem cell transplants of animal origin in several millions of patients over the last 80+ years has accumulated sufficient data to prove that stem cell xeno-transplantation is not dangerous to an individual patient or to a mankind.
- Cell xeno-transplantation has not caused a single fatality in ~70 million patients over 80+ years, or in any way jeopardized the future of mankind.
- Most researchers believe that xenotransplantation is exceedingly unlikely to lead to the generation of new pathogens providing that no laboratory “manipulation” is used in defiance of laws of Nature.
The above is particularly true if animal source of cell xeno-transplants is a domestic animal from closed colony with a traceable record, as required by U.S. FDA <1>PHS regulations. The key premise of the U.S. PHS regulations is to increase the safety of SCT for the benefit of the recipient patient, but also to minimize, or eliminate, any medico-legal exposure for the treating physician as well as the laboratory individually preparing stem cell transplants for each named patient.
One of the most exciting developments in the science of stem cell healing is the development of a product called ACTIVEITEM. It is a lyophilized extract of ovine (sheep) placenta and umbilical cord tissue rich in naturally occurring stem cells. It is produced exclusively by ACTIVEITEM, Inc. and available in capsule form. The stem cells initiate, promote, and guide the body’s healing response in every type of tissue by triggering the restoration and reprogramming your body’s own stem cells, which – when awakened and directed – work to make you healthy and more vital.
WHERE TO LEARN MORE
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